Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps.
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چکیده
منابع مشابه
Inhibition of low-density lipoprotein oxidation by astaxanthin.
Marine animals produce astaxanthin which is a carotenoid and antioxidant. In this study we determined the in vitro and ex vivo effects of astaxanthin on LDL oxidation. The oxidation of LDL was measured in a 1 ml reaction system consisting of increasing concentrations of astaxanthin (12.5, 25.0, 50.0 microg/ml), 400 microM V-70 (2, 2'-azobis(4-methoxy-2, 4-dimethylvaleronitrile)), and LDL (70 mi...
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Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...
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Antioxidant drugs and the inhibition of low-density lipoprotein oxidation Emma S. R. Green, Chris E. Cooper*, Michael J. Daviest and Catherine Rice-Evans Free Radical Research Group, Division of Biochemistry, UMDS-Guy's Hospital, Thomas's Street, London SE I 9RT, *Division of Biomolecular Sciences, King's College London, Campden Hill Road, London W8 7AH and +Department of Chemistry, University ...
متن کاملThe use of spin traps to investigate site-specific formation of free radicals in low-density lipoprotein oxidation.
Introduction It is currently believed that the oxidatively modified LDL plays a key role in the development of atherogenesis [ 1-31. Abundant data suggest that the oxidative modification of low-density lipoprotein (LDL) is mediated by lipid-derived free radicals, lipid hydroperoxides, or aldehydes derived from them [4-lo]. Although several oxidizing species have been shown to initiate the oxida...
متن کاملEnhancement by Glucose of Low Density Lipoprotein-Oxidation by Peroxynitrite8
Oxidation of low density lipoprotein (LDL) by copper ions is not influenced by glucose in a concentration range between 1 and 20 m M . LDL-oxidation by peroxynitrite or the simulta neous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Since both fre...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)46894-9